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Start Over Author "Shao-Xiang WANG" Topic enzyme inhibitors
1 results on '"Shao-Xiang WANG"'

1. SNX-2112, a Novel Hsp90 Inhibitor, Induces G2/M Cell Cycle Arrest and Apoptosis in MCF-7 Cells.

Author

Shao-Xiang WANG, Huai-Qiang Ju, Kai-Sheng Liu, Jia-Xuan ZHANG, Xiao WANG, Yang-Fei XIANG, Rui WANG, Jin-Yun Liu, Qiu-Ying Liu, Min XIA, Guo-Wen XING, Zhong LIU, and Yi-Fei WANG

Subjects
*HEAT shock proteins, *ENZYME inhibitors, *CELL growth, *APOPTOSIS, *CELL cycle, *BREAST cancer, *CANCER cells, *FLOW cytometry
Abstract

The article presents a study regarding the effects of SNX-2112 heat shock protein 90 (Hsp90) inhibitor on the inhibition of cell growth, apoptosis, and cycle in MCF-7 human breast cancer cells. The study indicate that the SNX-2112 inhibits cell growth in a dose- and time-dependent manner based on a 3-(4,5-dimethylthiazol-2-yl)-2-5-diphenyltetrazolium bromide (MTT) assay and flow cytometric analysis. The study has found the involve activation of mitochondrial apoptopic pathway in SNX-2112.

Published
2011
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