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This article presents topical issues devoted to the study and prospects for the development of enzyme preparations in modern pharmaceutical practice in the Republic of Uzbekistan. In the context of existing resources, the rational use of high-quality, effective, safe medicines and the creation of new ones by combining local raw materials with an innovative approach is a priority. The expediency of combinations of drugs useful for medical practice for effort or combination of effects is noted. In medicine, nonsteroidal anti-inflammatory drugs (NSAIDs) are commonly used to treat rheumatoid arthritis and other inflammatory diseases. NSAIDs are the basic drugs in the pharmacotherapy of many chronic, acute diseases, normalizing biochemical parameters and the functional state of blood cells. These drugs are taken over-the-counter and for a long time, and therefore resolving issues, related to the safety of their use, the search for a combination is relevant. Currently, domestic developments of NSAIDs (fensulkal, blizketazin) are being carried out by combining enzymes (to enhance the effect) and in justified rectal and transfermal medicinal forms. Many diseases are associated with impaired secondary enzyme deficiency. Clinical studies confirm the high effectiveness of the combination of NSAIDs with enzyme preparations. The classification of proteolytic enzymes, the importance, scale and resources of the prevalence of plant enzymes in the Republic are presented. Of particular interest is the papaya (melon tree). Papain and chymopapain are latex enzymes of the fruits of the melon tree. [ABSTRACT FROM AUTHOR]