1. Enterotoxigenic Escherichia coli diarrhea in children less than five years of age in central Java.
- Author
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Orndorff GR, Sadjimin T, Simanjuntak CH, O'Hanley P, Punjabi NH, Tjokrosonto S, Corwin A, Dibley M, Lebron CI, and Echeverria P
- Subjects
- Age Factors, Bacterial Toxins biosynthesis, Child, Preschool, Diarrhea microbiology, Diarrhea, Infantile microbiology, Escherichia coli Infections microbiology, Escherichia coli O157 pathogenicity, Female, Humans, Indonesia epidemiology, Infant, Male, Prevalence, Diarrhea epidemiology, Diarrhea, Infantile epidemiology, Enterotoxins biosynthesis, Escherichia coli Infections epidemiology, Escherichia coli O157 isolation & purification, Escherichia coli Proteins
- Abstract
A community-based prospective study was performed from December 1993 through March 31, 1994 in Indonesia in children less than five years of age. Enterotoxigenic Escherichia coli (ETEC) was identified in diarrheic stool by colony hybridization assay, using toxin probes, and this bacterium was isolated from 19% of 340 episodes of diarrhea. Sixty-one percent of ETEC produced heat-labile toxin (LT) only, 325 LT and heat-stable toxin (ST), and 75 ST only. The age-specific incidence rates of diarrhea among children 0-1 and 2-3 years of age were 77% and 61%, respectively, during the study period; ETEC was isolated from 26% of children 0-1 years of age versus 53% for children 2-3 years of age. As many as seven episodes of diarrhea were repeatedly experienced by a single child during the four-month study period; however, only two children had more than one episode of known ETEC-associated diarrheal disease during the period of observation.
- Published
- 1996
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