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The Enterococcus faecalis are microorganisms frequently found in persistent endodontic infections and are probably the best species to adapt to and tolerate the poor ecological conditions in root canal obturation. In order to show which characteristics make E. faecalis so resistant and to verify its susceptibility to different antimicrobial agents, a broad literature review of the literature was performed aiming to analyze the performance of the intracanal medication on this etiologic agent. The search was based on access to the Pubmed and Bireme databases. Fifty manuscripts met the inclusion criteria and were used in this review. The results showed that E. feacalis a rapid recovery from nutritional deprivation and environmental stress, has strong factors of viirulence and is located in places difficult to reach the endodontist. When submitted to different intracanal medicinal products, E. faecalis had a higher susceptibility to those containing chlorhexidine. However, this bacterium still presents a high level of complexity in its elimination and a potential risk to endodontic failure. [ABSTRACT FROM AUTHOR]