1. Effects of cerium oxide nanoparticles on the growth of keratinocytes, fibroblasts and vascular endothelial cells in cutaneous wound healing.
- Author
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Chigurupati S, Mughal MR, Okun E, Das S, Kumar A, McCaffery M, Seal S, and Mattson MP
- Subjects
- Animals, Antioxidants chemistry, Cell Movement drug effects, Cell Proliferation drug effects, Cells, Cultured, Cerium chemistry, Endothelial Cells cytology, Fibroblasts cytology, Fibroblasts drug effects, Fluorescent Antibody Technique, Humans, Keratinocytes cytology, Mice, Mice, Inbred C57BL, Oxidative Stress, Skin drug effects, Skin injuries, Antioxidants pharmacology, Cerium pharmacology, Endothelial Cells drug effects, Keratinocytes drug effects, Nanoparticles chemistry, Wound Healing drug effects
- Abstract
Rapid and effective wound healing requires a coordinated cellular response involving fibroblasts, keratinocytes and vascular endothelial cells (VECs). Impaired wound healing can result in multiple adverse health outcomes and, although antibiotics can forestall infection, treatments that accelerate wound healing are lacking. We now report that topical application of water soluble cerium oxide nanoparticles (Nanoceria) accelerates the healing of full-thickness dermal wounds in mice by a mechanism that involves enhancement of the proliferation and migration of fibroblasts, keratinocytes and VECs. The Nanoceria penetrated into the wound tissue and reduced oxidative damage to cellular membranes and proteins, suggesting a therapeutic potential for topical treatment of wounds with antioxidant nanoparticles., (Published by Elsevier Ltd.)
- Published
- 2013
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