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The present article was designed to illustrate the potential for the combined treatment of a orolaryngopharyngeal papilloma under the conditions of an out-patient setting with the application of the minimally invasive endoscopic surgical intervention, the so-called photodynamic therapy (PDT). The authors describe the clinical case which demonstrate the possibilities for using photodynamic therapy as a component of the combined treatment of papilloma of the hypopharynx including its radical removal. The application of the PDT mdethod in the clinical case reported in the present article was aimed at preventing the recurrence of papillomatosis of the upper respiratory tract. The evaluation of the outcome of the treatment of the patient in the course of the follow-up period is expected to provide the data for the assessment of the clinical effectiveness of the adjuvant PDT technique.