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Objective: To study the expression of growth differentiation factor 15 (GDF-15) and phosphorylated mammalian target of rapamycin(p-mTOR)in endometrial carcinoma, and analysis of its clinical significance, and analysis of its clinical significance, to provide basis for clinical treatment. Methods: 75 cases of endometrial carcinoma from January 2011 to February 2016 in our hospital were selected as the study group, another 75 cases of normal endometrial tissue were selected as control group, the expression of GDF-15 and p-mTOR protein was detected by immunohistochemistry. Results: The expression positive rate of GDF-15 and p-mTOR protein in the study group was significantly higher than that in the control group, the difference was statistically significant (P<0.05); GDF-15 and p-mTOR protein expression positive rate of endometrial cancer stage III-IV, lymph node metastasis, Pathological grading G2+G3, muscular layer infiltration depth≥ 1 / 2 were higher (P<0.05); positive correlation between GDF-15 and p-mTOR protein in endometrial carcinoma tissue (P<0.05). Conclusion: Increased expression of GDF-15 and p-mTOR protein in endometrial carcinoma, and the tumor metastasis, clinical stage, the depth of the depth of the muscle invasion. [ABSTRACT FROM AUTHOR]

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