1. Increased Endothelial Dysfunction and Insulin Resistance in Patients with Klinefelter Syndrome
- Author
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Fatih Yesildal, Coskun Meric, Alper Sonmez, Deniz Torun, Aydogan Aydogdu, Yalcin Basaran, Cem Haymana, Ibrahim Demirci, Orhan Demir, Mustafa Dinc, and Omer Azal
- Subjects
Blood Glucose ,Male ,0301 basic medicine ,medicine.medical_specialty ,Turkey ,Endocrinology, Diabetes and Metabolism ,medicine.medical_treatment ,Population ,030209 endocrinology & metabolism ,Arginine ,Young Adult ,03 medical and health sciences ,chemistry.chemical_compound ,Klinefelter Syndrome ,0302 clinical medicine ,High-density lipoprotein ,Insulin resistance ,Risk Factors ,Internal medicine ,Prevalence ,medicine ,Humans ,Insulin ,Immunology and Allergy ,Testosterone ,Endothelial dysfunction ,education ,Inflammation ,education.field_of_study ,business.industry ,Cholesterol, HDL ,medicine.disease ,C-Reactive Protein ,030104 developmental biology ,Endocrinology ,chemistry ,Cardiovascular Diseases ,Case-Control Studies ,Multivariate Analysis ,Homeostatic model assessment ,Endothelium, Vascular ,Inflammation Mediators ,Insulin Resistance ,Klinefelter syndrome ,business ,Asymmetric dimethylarginine ,Biomarkers - Abstract
BACKGROUND AND OBJECTIVE Patients with Klinefelter Syndrome (KS) have increased cardiometabolic risk however the pathogenesis is not clear. We investigated the presence of endothelial dysfunction, insulin resistance and inflammation in an unconfounded population of KS. METHODS A total of 32 patients with KS (mean age 21.59 ± 1.66 years) and 33 healthy control subjects (mean age: 22.15 ± 1.03 years) were enrolled. The demographic parameters, Asymmetric dimethylarginine (ADMA), homeostatic model assessment of insulin resistance (HOMA-IR) index and highsensitivity C-reactive protein (hs-CRP) levels were measured. RESULTS The patients had higher Follicle Stimulating Hormone (FSH), Luteinizing Hormone (LH), insulin, HOMA-IR and ADMA levels (p < 0.001 for all) and lower High Density Lipoprotein Cholesterol (HDL-C) and total testosterone levels (p=0.002 and p
- Published
- 2018