1. Characteristics and natural history of patients with colorectal cancer complicated by infectious endocarditis. Case control study of 25 patients.
- Author
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Ouaïssi M, Studer AS, Mege D, Thuny F, Boiron L, Loundou A, Pirrò N, Hamed S, Frasconi C, Habib G, Fournier PE, Collart F, Sielezneff I, and Sastre B
- Subjects
- Aged, Aged, 80 and over, Case-Control Studies, Colorectal Neoplasms etiology, Colorectal Neoplasms surgery, Echocardiography, Transesophageal, Endocarditis, Bacterial microbiology, Female, Follow-Up Studies, Humans, Male, Middle Aged, Neoplasm Staging, Prognosis, Prospective Studies, Streptococcal Infections microbiology, Survival Rate, Colorectal Neoplasms mortality, Endocarditis, Bacterial complications, Streptococcal Infections complications, Streptococcus isolation & purification
- Abstract
Unlabelled: Association between streptococcal endocarditis and gastrointestinal disease has been well-documented in the literature. However oncological impact of this complicated presentation has not yet been reported. We have conducted to our knowledgethe first case-control study on this subject., Patients and Methods: Two groups of five patients with colorectal cancer and either active endocarditis (CRC E+), or without endocarditis (CRC, n=20) were matched 1:4 for age, sex, and location of colorectal tumor., Results: All 25 patients were male, with a median age of 63 (range: 53-85) years. Twenty (80%) had colon cancer and 5 (20%) rectal cancer. There was no post-operative mortality in this population. The overall morbidity was 28% (n=7). The overall 3-year survival and recurrence rates were similar in both groups 80% and 95%; 0% and 30% for group CRC E+ and CRC (p=0.4603)., Conclusion: This is the first case-control study demonstrating that during the first two years of follow-up, occurrence of endocarditis did not alter the prognosis of patients with CRC.
- Published
- 2014