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Your search keyword '"Sayago, Francisco J."' showing total 3 results
Start Over Author "Sayago, Francisco J." Topic enantioselectivity
3 results on '"Sayago, Francisco J."'

1. Synthesis of [c]-fused bicyclic proline analogues

Author

Calaza, M. Isabel, Sayago, Francisco J., Laborda, Pedro, Cativiela, Carlos, and Russian Foundation for Basic Research

Subjects
Diastereoselectivity, Nitrogen heterocycles, Proline analogues, Amino acids, Enantioselectivity
Abstract

An overview of synthetic methods developed to build [c]fused bicyclic proline analogues is presented. The focus is on the preparation of azabicycles that bear a carbocyclic ring fused to the [c] face of the pyrrolidine unit. Attention is paid both to procedures that afford the desired compounds in racemic form and to asymmetric strategies. Procedures are or-ganized according to the size of the carbocycle that is fused to the pyrrolidine moiety. Strategies able to provide multigram quantities of enantiopure compounds that have application in the synthesis of marketed drugs are highlighted., This study was supported by the Russian Foundation for Basic Research (RFBR), Russia (Projects No. 14-03-31685, 14-03-31709, 14-03-01114).

Published
2015

2. Organocatalyzed Michael Addition Reaction by Novel (2R,3aS,7aS)-Octa-hydroindole-2-carboxylic Acid, a New Fused Proline.

Author

Roca-L�pez, David, Merino, Pedro, Sayago, Francisco J., Cativiela, Carlos, and Herrera, Raquel P.

Subjects
ORGANOCATALYSIS, MICHAEL reaction, CARBOXYLIC acids, PROLINE, NITROALKENES, CATALYSTS
Abstract

We present here the results obtained in our study on organocatalytic enantioselective Michael addition reaction of acetone to different nitroolefines using (2R,3aS,7aS)-octahydroindole-2-carboxylic acid [(R,S,S)-Oic] as a new and suitable catalyst for this process. Computational calculations support the results obtained with (R,S,S)-Oic versus its diastereomeric form (S,S,S)-Oic. The final products are obtained in good yields and moderate enantioselectivities (up to 58% ee). [ABSTRACT FROM AUTHOR]

Published
2011
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3. Organocatalyzed Michael Addition Reaction by Novel (2R,3aS,7aS)-Octahydroindole- 2-carboxylic Acid, a New Fused Proline.

Author

Roca-López, David, Merino, Pedro, Sayago, Francisco J., Cativiela, Carlos, and Herrera, Raquel P.

Subjects
CARBOXYLIC acids, PROLINE, ENANTIOSELECTIVE catalysis, ACETONE, NITROALKENES
Abstract

We present here the results obtained in our study on organocatalytic enantioselective Michael addition reaction of acetone to different nitroolefines using (2R,3aS,7aS)-octahydroindole-2-carboxylic acid [(R,S,S)-Oic] as a new and suitable catalyst for this process. Computational calculations support the results obtained with (R,S,S)-Oic versus its diastereomeric form (S,S,S)-Oic. The final products are obtained in good yields and moderate enantioselectivities (up to 58% ee). [ABSTRACT FROM AUTHOR]

Published
2011
Full Text
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