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The enantioselective amination of Morita–Baylis–Hillman carbonates with silylated derivatives of tert-butylhydroxycarbamates using β-isocupreidine as an organocatalyst was investigated. The corresponding products were obtained in good yields with high enantioselectivities. The scope and limitations of the reported protocol were explored, and representative transformations of the adducts toward heterocyclic compounds were highlighted. [ABSTRACT FROM AUTHOR]

Abstract: The highly enantioselective organocatalytic α-selenylation reaction of aldehydes using a hypervalent iodine compound as an oxidative agent from commercially available phenyl diselenide under mild oxidative conditions is described. This transformation affords α-selenyl aldehydes in good yields and with excellent enantioselectivities. By using hypervalent iodine compounds, it opens up a suitable and alternative way for the preparation of biologically active building blocks such as β-hydroxy alcohols, α-amino acids, and α-hydroxy esters. [Copyright &y& Elsevier]

The successful α-selenylation methodology is also applicable to β-keto esters like (V). [ABSTRACT FROM AUTHOR]