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The application of the G-SERFph pulse sequence is presented on enantiomeric mixtures dissolved in a chiral liquid crystal. It aims at editing, within one single 2D spectrum, every proton coupling which is experienced by a given proton site in the molecule, and leads to real phased T-edited spectroscopy (T=J+2D). This NMR experiment is based on the combination of homonuclear semi-selective refocusing techniques with a spatial frequency encoding of the sample. This approach, which consists in handling selectively each coupling in separate cross sections of the sample, is applied to the visualization of enantiomers dissolved in a chiral liquid crystalline phase. Advantages and limits of this methodology are widely discussed.

NMR spectroscopy using chiral liquid crystals as solvents is a powerful tool to visualize enantiomers. Using these oriented solvents, recent NMR studies with selective excitation have proven their effectiveness at simplifying enantiomeric visualization and enantiomeric excess determination through 1H or 13C spectra. In this review we present different straightforward and robust selective techniques dedicated to the spectral analysis of enantiomers dissolved in such chiral-oriented solvents.

NMR spectroscopy using chiral liquid crystals as solvents is a powerful tool to visualize enantiomers. Using these oriented solvents, recent NMR studies with selective excitation have proven their effectiveness at simplifying enantiomeric visualization and enantiomeric excess determination through 1H or 13C spectra. In this review we present different straightforward and robust selective techniques dedicated to the spectral analysis of enantiomers dissolved in such chiral-oriented solvents.