1. Improved Cardiac Iron One Year After Including Rapid Magnetic Resonance Imaging Scanning in a Thalassaemia Medical Camp: Ultrafast MRI For Iron Management in India – The UMIMI Study
- Author
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Sanjiv Sharma, Surya Pratap, Louise McGrath, Judith Walker, Emmanuel Ako, John Walker, James C. Moon, Harsh Mahajan, Nabila Mughal, Tenzin Seldon, Amna Abdel-Gadir, Prabhar Srivastava, Alexander Rikowski, Vineeta Ojha, VK Kanna, Kartik P. Ganga, Rajiv Kumar Bansal, Vidhur Mahajan, Amita Mahajan, Redha Boubertakh, Katia D. Menacho Medina, João B Augusto, and Tulika Seth
- Subjects
medicine.medical_specialty ,medicine.diagnostic_test ,business.industry ,Thalassemia ,Magnetic resonance imaging ,medicine.disease ,Middle income country ,Heart failure ,Emergency medicine ,medicine ,Cardiac iron ,Transfusion dependent thalassemia ,Chelation therapy ,Siderosis ,business - Abstract
Background: Survival in transfusion dependent thalassemia is closely linked to iron overload with severe cardiac iron causing heart failure. MRI guided chelation improves survival in high income countries. We explored the use of rapid MRI to guide therapy in a Lower Middle Income Country (LMIC), India, via locally organized thalassemia patient medical camps. Methods: Rapid cardiac MRI (rCMR) was implemented at two sites with clinical assessment and therapy recommendations based on rCMR findings. Investigations and clinical reassessment were repeated at 13 months. Findings: The baseline visit was attended by 103 patients, the second by 86. Average time of scanning was 10 minutes. At baseline 29% had a cardiac T2* = 17ms). At 13 months more patients were taking 2 oral chelators (21% to 37%, p
- Published
- 2021
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