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The aim of the present study was to investigate the association between vitamin D receptor (VDR) gene polymorphisms and musculoskeletal injury (MI) in elite football players. In total, 54 male professional football players were recruited from an official Italian professional championship team between 2009 and 2013. The cohort was genotyped for the ApaI, BsmI and FokI polymorphisms and MI data were collected over four football seasons. No significant differences were identified among the genotypes in the incidence rates or severity of MI (P=0.254). In addition, no significant associations were observed between VDR polymorphisms and MI phenotypes (P=0.460). However, the results of the casewise multiple regression analysis indicated that the ApaI genotypes accounted for 18% of injury severity (P=0.002). Therefore, while the BsmI and FokI polymorphisms did not appear to be associated with the severity or incidence of MI, the ApaI genotypes may have influenced the severity of muscle injury in top-level football players. [ABSTRACT FROM AUTHOR]

While VO has been widely investigated, there is few research on anaerobic capacity (AC) in soccer players. Previous studies reported that AC is age-dependent and that young individuals had lower AC compared with adults. Thus, we wondered whether AC would have proven more useful than VO in differentiating adult soccer players from young players. A total of 37 male athletes from a professional team were recruited and divided into two sub-groups: the adult (AD, n = 20) group, older than 19 years, and the young (YO, n = 17) group, ranged from 16 to 18 years. Each participant underwent an incremental test on a treadmill to assess maximal velocity ( V), anaerobic threshold (AT) and VO and a supramaximal exercise at a velocity 10 % higher than V to measure AC. The AD group reached higher AT and VO with respect to the YO group (55.23 ± 4.65 vs. 51.48 ± 4.73 mL min kg), whereas no difference was found in parameters related to the AC. In conclusion, young soccer players had the same AC as adult, but they displayed a lower VO. These findings indicated that AC in professional players is fully developed already when they are young while aerobic capacity is still to be developed. [ABSTRACT FROM AUTHOR]

Objective: The ACTN3 R577X gene variant results in the absence of the α-actinin-3 protein in ∼18% of humans worldwide and has been associated with athletic performance and increased susceptibility to eccentric muscle damage. The aim of this study was to investigate the association between ACTN3 R577X variant and indirect muscle disorders/injuries in professional football players. Design: A case–control, genotype–phenotype association study. Intervention: Two hundred fifty-seven male professional Italian football players (from Serie A, Primavera, Allievi, and Giovanissimi; age = 21.2 ± 5.3 years) and 265 nonathletic controls were recruited for the study. Genomic DNA was extracted using a buccal swab, and the ACTN3 R577X genotype was performed using a PCR method. Structural–mechanical injuries and functional muscle disorders were collected from a subgroup of 169 football players during the period of 2009 to 2014. Main Outcome Measure: We hypothesized that the 577XX genotype would be associated with higher predisposition to muscle injuries (compared with the other genotypes). Results: ACTN3 XX (α-actinin-3 deficiency) players had 2.66 higher odds for an injury incidence than their ACTN3 RR counterparts (95% confidence interval [CI]: 1.09-6.63, P = 0.02), whereas RX and RR players had similar injury incidence. Furthermore, ACTN3 XX players had 2.13 higher odds for having a severe injury compared with their RR counterparts (95% CI: 1.25-3.74, P = 0.0054), whereas RX individuals had 1.63 higher odds for having a severe injury compared with the RR players (95% CI: 1.10-2.40, P = 0.015). Conclusions: The ACTN3 R577X polymorphism is associated with the incidence and severity of muscle injuries in professional football players; players with the ACTN3 577XX genotype have higher odds of having muscle injuries than their RR counterparts. Clinical Relevance: Discovering the complex relationship between gene variants and muscle injuries may assist coaches, physiologists, and the medical community to development tailored injury prevention program for football players, which could provide a new edge for successful competition. [ABSTRACT FROM AUTHOR]