1. Spectrum of antibody profiles in tuberculous elephants, cervids, and cattle.
- Author
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Lyashchenko, Konstantin P., Gortázar, Christian, Miller, Michele A., and Waters, W. Ray
- Subjects
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MYCOBACTERIUM tuberculosis , *TUBERCULOSIS in cattle , *CERVIDAE , *ELEPHANT diseases , *IMMUNOGLOBULINS , *IMMUNE recognition , *DISEASES - Abstract
Using multi-antigen print immunoassay and DPP ® VetTB Assay approved in the United States for testing captive cervids and elephants, we analyzed antibody recognition of MPB83 and CFP10/ESAT-6 antigens in Asian elephants ( Elephas maximus ) infected with Mycobacterium tuberculosis and in white-tailed deer ( Odocoileus virginianus ), fallow deer ( Dama dama ), elk ( Cervus elaphus ), and cattle ( Bos taurus ) infected with Mycobacterium bovis. Serum IgG reactivity to MPB83 was found in the vast majority of tuberculous cattle and cervid species among which white-tailed deer and elk also showed significant CFP10/ESAT-6 recognition rates with added serodiagnostic value. In contrast, the infected elephants developed antibody responses mainly to CFP10/ESAT-6 with MPB83 reactivity being relatively low. The findings demonstrate distinct patterns of predominant antigen recognition by different animal hosts in tuberculosis. [ABSTRACT FROM AUTHOR]
- Published
- 2018
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