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Electrospinning has been introduced as an efficient technique for the fabrication of polymeric nanofibers. Electrospun nanofibrous structures have gained an unprecedented application among other nanostructures in drug delivery owing to their high surface area, which enable drugs to be adhered on the surface of the nanofibers. Our concept was to fabricate electrospun nanofibers and then immobilize drug-loaded polyeric micro- and nanoparticles into electrospun nanofibers. In our studies, artemisone (ART) as an antiplasmodial anti-inflamatory medication was used. By immobilizing ART into micro and nanocarriers, we aimed at increasing the stability as well as protecting the drug from degradation in aqueous medium and more importantly reducing the amount of burst release along with prolonging the release rate. We developed different carriers such as ART-loaded micro and nanoparticles synthesized by spray drying and solvent-displacement method. We were aiming at optimizing the governing parameters, which substantially influences particle size and encapsulation efficiency. It is important to produce particles with an efficient amount of drug and achieve the highest encapsulation efficiencies especially in case of ART, which is an expensive drug. Our concept was to immobilize these ART-loaded nanoparticles in electrospun nanofibers to evaluate whether we can merit from both advantages of nanoparticle and nanofiber. Our results proved our concept that the electrospun nanofibers immobilized with ART-loaded nanoparticles showed less burst release and more sustained release compared to nanoparticles and nanofibers itself. In other work, we tried to immobilize ART-loaded micro and nanoparticle in electrospun nanofibers simeltaneously by conducting suspension electrospinning to have an understanding of how the particle size impacts the ART release from electrospun nanofibers. Using this concept, the ART-loaded micro and nanoparticles immobilized in electrospun nanofibers revealed a less burst release and a more sustained release compared to fibers without particles. We also employed core-shell electrospinning as a concept to encapsulate ART into electrospun nanofibers. We achieved the core-shell structure, which resulted in a sustained release as well as less burst release compared to other systems. Lastly, we electrospun two types of cellulose namely MCC and CP, which resulted in obtaining nanofibers with a unique structure. The obtained nanofiber could be loaded with ART and find application for drug delivery.