1. Production of the biomimetic small diameter blood vessels for cardiovascular tissue engineering.
- Author
-
Aydogdu, Mehmet Onur, Chou, Joshua, Altun, Esra, Ekren, Nazmi, Cakmak, Selami, Eroglu, Mehmet, Osman, Asila A., Kutlu, Ozlem, Oner, Ebru Toksoy, Avsar, Gulben, Oktar, Faik Nuzhet, Yilmaz, Ismail, and Gunduz, Oguzhan
- Subjects
BIOMIMETIC materials ,BLOOD vessels ,TISSUE engineering ,ETHYLCELLULOSE ,FOURIER transform infrared spectroscopy ,BIOPOLYMERS - Abstract
A novel biomimetic vascular graft scaffolds were produced by electrospinning method with the most superior characteristics to be a proper biomimetic small diameter blood vessel using Polycaprolactone(PCL), Ethyl Cellulose(EC) and Collagen Type-1 were used to create the most convenient synergy of a natural and synthetic polymer to achieve similarity to native small diameter blood vessels. Scanning Electron Microscopy(SEM), Fourier Transform Infrared Spectroscopy(FTIR), Differential Scanning Calorimetry Analysis(DSC), tensile measurement tests, and in-vitro and in-vivo applications were performed. Results indicated significant properties such as having 39.33 nm minimum, 104.98 nm average fiber diameter, 3.2 MPa young modulus and 135% relative cell viability. [ABSTRACT FROM AUTHOR]
- Published
- 2019
- Full Text
- View/download PDF