1. The research and preparation of a novel nano biodegradable polymer external reinforcement
- Author
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Zhang, Xiangman, Chen, Bin, Fu, Weiguo, Fang, Zhengdong, Liu, Zhenjie, Lu, Weifeng, Shi, Zhengyu, Chen, Lili, and Chen, Tao
- Subjects
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BIODEGRADATION , *POLYMERS , *NANOSTRUCTURED materials , *TISSUE scaffolds , *CONTROLLED release drugs , *CLINICAL trials , *GLUTAMIC acid polymers , *BLOCK copolymers , *WATER-soluble polymers , *ELECTROSPINNING , *MICELLES - Abstract
Abstract: The use of current drug-loaded vascular scaffolds is limited in sustained drug release and stability studies in clinical and preclinical trials. We found that poly(l-glutamic acid)-b-poly(propylene oxide)-b-poly(l-glutamic acid) (PLGA-b-PPO-b-PLGA) triblock copolymers can deliver multiple poorly water-soluble drugs (e.g., Paclitaxel) at clinically relevant doses. In this study, we synthesized a new drug-loaded vascular external graft with electrospun nanofibrous scaffolds [poly(l-lactide-co-ɛ-caprolactone) (PLCL):fibrinogen; 2:1 (w/w)] and drug-loaded PLGA-b-PPO-b-PLGA micelles. Cell proliferation and viability assay results showed that beagle smooth muscle cells grew well on the surface of vascular graft-coated micelles at a percentages of 10% (w/w) GPG:PLCL–fibrinogen. This study demonstrates that micelle-coated electrospun PLCL–fibrinogen vascular scaffolds have potential applications in vascular tissue engineering. [Copyright &y& Elsevier]
- Published
- 2011
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