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Pavlovian fear conditioning is widely used as a laboratory model of associative learning in human and nonhuman species. In this model, an organism is trained to predict an aversive unconditioned stimulus from initially neutral events (conditioned stimuli, CS). In humans, fear memory is typically measured via conditioned autonomic responses or fear-potentiated startle. For the latter, various analysis approaches have been developed, but a systematic comparison of competing methodologies is lacking. Here, we investigate the suitability of a model-based approach to startle eyeblink analysis for assessment of fear memory, and compare this to extant analysis strategies. First, we build a psychophysiological model (PsPM) on a generic startle response. Then, we optimize and validate this PsPM on three independent fear-conditioning data sets. We demonstrate that our model can robustly distinguish aversive (CS+) from nonaversive stimuli (CS-, i.e., has high predictive validity). Importantly, our model-based approach captures fear-potentiated startle during fear retention as well as fear acquisition. Our results establish a PsPM-based approach to assessment of fear-potentiated startle, and qualify previous peak-scoring methods. Our proposed model represents a generic startle response and can potentially be used beyond fear conditioning, for example, to quantify affective startle modulation or prepulse inhibition of the acoustic startle response. [ABSTRACT FROM AUTHOR]

Startle stimuli elicit various physiological and cognitive responses. This study investigated whether acoustic startle stimuli affect saccadic reactions in an emotional pro- or antisaccade task. Startle probes were presented either 500 ms before or simultaneous with an imperative stimulus that indicated whether a saccade towards or away from positive, neutral, or negative peripheral target pictures had to be performed. Valence interacted with saccade direction according to an approach-avoidance pattern of gaze behavior, with delayed prosaccades to negative targets and antisaccades away from positive targets. Acoustic startle stimuli preceding the presentation of peripheral target pictures speeded up the initiation saccades, irrespective of stimulus valence. Results indicate a speeding of cognitive-motor processing by preceding startle stimuli. [ABSTRACT FROM AUTHOR]

Abstract: Behavioral evidence suggests that emotion processing deficits in individuals with autism spectrum disorders (ASD) may occur at the level of basic (early, rapid, automatic) affective processes. Consistently, neurological evidence indicates that key brain areas associated with basic affective processing are atypical in ASD. The current study sought to better specify these deficits by comparing different components of basic affective processing in 14 adolescents and adults with ASD and 14 typical controls matched for age and verbal ability. Participants viewed affective pictures, and their responses were assessed with (i) affective eyeblink startle modulation, an indicator of the brain''s aversive motivational system; (ii) facial electromyography, an online indicator of implicit valence appraisal; and (iii) self-report, an indicator of overt valence appraisal. The results show that in contrast to the typical pattern, in which exposure to negative stimuli increases startle whereas exposure to positive stimuli decreases startle, individuals with ASD showed startle potentiation to both positive and negative stimuli. Atypical potentiation during positive stimuli occurred despite individuals with ASD demonstrating appropriate implicit valence appraisals, reflected in their facial EMG responses, and appropriate overt appraisals, reflected in their self-reported ratings of the stimuli. Potentiation of startle to both positive and negative stimuli suggests a disruption in basic affective processes in ASD at the level of the early motivational response. This atypical pattern of responses has implications for understanding social and emotion deficits in ASD and calls for further investigation of basic affective processes. [Copyright &y& Elsevier]