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Your search keyword '"V. Onofrj"' showing total 3 results
Start Over Author "V. Onofrj" Topic electroencephalography
3 results on '"V. Onofrj"'

1. "Small World" architecture in brain connectivity and hippocampal volume in Alzheimer's disease: a study via graph theory from EEG data.

Author

Vecchio F, Miraglia F, Piludu F, Granata G, Romanello R, Caulo M, Onofrj V, Bramanti P, Colosimo C, and Rossini PM

Subjects
Aged, Alzheimer Disease pathology, Computer Simulation, Female, Hippocampus pathology, Humans, Male, Nerve Net pathology, Neural Pathways pathology, Neural Pathways physiopathology, Organ Size, Alzheimer Disease physiopathology, Brain Waves, Connectome methods, Electroencephalography methods, Hippocampus physiopathology, Models, Neurological, Nerve Net physiopathology
Abstract

Brain imaging plays an important role in the study of Alzheimer's disease (AD), where atrophy has been found to occur in the hippocampal formation during the very early disease stages and to progress in parallel with the disease's evolution. The aim of the present study was to evaluate a possible correlation between "Small World" characteristics of the brain connectivity architecture-as extracted from EEG recordings-and hippocampal volume in AD patients. A dataset of 144 subjects, including 110 AD (MMSE 21.3) and 34 healthy Nold (MMSE 29.8) individuals, was evaluated. Weighted and undirected networks were built by the eLORETA solutions of the cortical sources' activities moving from EEG recordings. The evaluation of the hippocampal volume was carried out on a subgroup of 60 AD patients who received a high-resolution T1-weighted sequence and underwent processing for surface-based cortex reconstruction and volumetric segmentation using the Freesurfer image analysis software. Results showed that, quantitatively, more correlation was observed in the right hemisphere, but the same trend was seen in both hemispheres. Alpha band connectivity was negatively correlated, while slow (delta) and fast-frequency (beta, gamma) bands positively correlated with hippocampal volume. Namely, the larger the hippocampal volume, the lower the alpha and the higher the delta, beta, and gamma Small World characteristics of connectivity. Accordingly, the Small World connectivity pattern could represent a functional counterpart of structural hippocampal atrophying and related-network disconnection.

Published
2017
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2. Revisiting P300 cognitive studies for dementia diagnosis: Early dementia with Lewy bodies (DLB) and Alzheimer disease (AD).

Author

Bonanni L, Franciotti R, Onofrj V, Anzellotti F, Mancino E, Monaco D, Gambi F, Manzoli L, Thomas A, and Onofrj M

Subjects
Aged, Alzheimer Disease psychology, Cognition Disorders diagnosis, Female, Humans, Lewy Body Disease psychology, Male, Middle Aged, Neuropsychological Tests, Psychiatric Status Rating Scales, Reproducibility of Results, Socioeconomic Factors, Alzheimer Disease diagnosis, Alzheimer Disease physiopathology, Cognition physiology, Electroencephalography methods, Event-Related Potentials, P300 physiology, Lewy Body Disease diagnosis, Lewy Body Disease physiopathology
Abstract

Aims of the Study: Earlier P300 studies were conducted when the prevalence of dementia with Lewy Bodies (DLB) was unknown. Our study aims to examine whether P300 abnormalities are present in DLB and to evidence possible differences between DLB and Alzheimer's disease (AD). A second aim of this study is to look for correlations between P300 recordings and EEG, as abnormal EEG variability has been described in DLB., Patients and Methods: Auditory P300 responses were recorded by a classic oddball paradigm in 50 controls, in 36 DLB patients, and in 40 AD patients with MMSE>20., Results: Reliable auditory P300 responses were obtained in 26 DLB (72%), 33 AD (82.5%), and 46 controls (92%). P300 was more delayed and had lower amplitude in DLB compared to AD groups. P300 topography was also different as the anterior-to-posterior scalp amplitude gradient was reversed in DLB. P300 latency correlated with neuropsychological test scores and with EEG variables. Gradient inversion and delayed P300 responses in frontal derivations evidenced differences between DLB and AD patients with a sensitivity of 70% and a specificity of 97%., Conclusions: P300 recordings are abnormal in DLB and can be useful to distinguish DLB from AD., (Copyright © 2010 Elsevier Masson SAS. All rights reserved.)

Published
2010
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3. Revisiting P300 cognitive studies for dementia diagnosis: Early dementia with Lewy bodies (DLB) and Alzheimer disease (AD)

Author

V. Onofrj, E. Mancino, Laura Bonanni, Lamberto Manzoli, Astrid Thomas, Marco Onofrj, Francesca Anzellotti, Francesco Gambi, D. Monaco, and Raffaella Franciotti

Subjects
Lewy Body Disease, Male, medicine.medical_specialty, Socio-culturale, Audiology, Electroencephalography, Neuropsychological Tests, behavioral disciplines and activities, Central nervous system disease, Degenerative disease, Cognition, Alzheimer Disease, Physiology (medical), mental disorders, medicine, Humans, Oddball paradigm, Aged, Psychiatric Status Rating Scales, medicine.diagnostic_test, Dementia with Lewy bodies, Reproducibility of Results, General Medicine, Neuropsychological test, Middle Aged, medicine.disease, Event-Related Potentials, P300, nervous system diseases, medicine.anatomical_structure, nervous system, Neurology, Socioeconomic Factors, Scalp, Female, Neurology (clinical), Alzheimer's disease, Psychology, Cognition Disorders, Neuroscience
Abstract

Summary Aims of the study Earlier P300 studies were conducted when the prevalence of dementia with Lewy Bodies (DLB) was unknown. Our study aims to examine whether P300 abnormalities are present in DLB and to evidence possible differences between DLB and Alzheimer's disease (AD). A second aim of this study is to look for correlations between P300 recordings and EEG, as abnormal EEG variability has been described in DLB. Patients and methods Auditory P300 responses were recorded by a classic oddball paradigm in 50 controls, in 36 DLB patients, and in 40 AD patients with MMSE > 20. Results Reliable auditory P300 responses were obtained in 26 DLB (72%), 33 AD (82.5%), and 46 controls (92%). P300 was more delayed and had lower amplitude in DLB compared to AD groups. P300 topography was also different as the anterior-to-posterior scalp amplitude gradient was reversed in DLB. P300 latency correlated with neuropsychological test scores and with EEG variables. Gradient inversion and delayed P300 responses in frontal derivations evidenced differences between DLB and AD patients with a sensitivity of 70% and a specificity of 97%. Conclusions P300 recordings are abnormal in DLB and can be useful to distinguish DLB from AD.

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