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Background and Objective: Intraoperative awareness refers that patients can recall aspects of their surgery after being put under general anesthesia. This distressing complication causes affected patients to be conscious and probably feel pain, leading to emotional trauma or other sequelae. Monitoring and administrating the depth of anesthesia is necessary to prevent patients from awareness during a medical operation. In this paper, we analyzed the electroencephalograms (EEGs) of patients to characterize their anesthesia. The data set, "awareness" and "anesthesia" groups, each contained 558 samples, including patients who had undergone different types of surgeries., Methods: EEG signals acquired from patients in an aware state or under anesthesia were decomposed into a set of intrinsic mode functions (IMFs) through empirical mode decomposition (EMD). Fast Fourier transform (FFT) and Hilbert transform (HT) analyses were then performed on each IMF to determine the frequency spectra. The probability distributions of expected values of frequencies were generated for the same IMF in the two groups of patients. The corresponding statistical data, including analysis of variance tests, were also calculated. A receiver operating characteristic curve was used to identify optimal frequency value to discriminate between the two states of consciousness., Results: The frequencies of the IMFs for aware patients were found to be higher than those for anesthetized patients. The optimal frequency threshold by using FFT (or HT) for IMF 1 was 21.08 (or 25.00) Hz. IMF1 performed the highest with respect to the area under the curve (AUC) of 0.993 for FFT (or 0.989 for HT); hence it can be applied as a useful classifier to distinguish between fully anesthetized patients and aware patients., Conclusions: This paper proposes a method for identifying whether patients' state of consciousness during a range of surgery types is "under anesthesia" or "aware." Our method involves using EEG to characterize the depth of anesthesia through two frequency analysis techniques. On the basis of our analyses, we conclude that the performance of IMF1 is satisfactory in distinguishing between patients' states of consciousness during surgery requiring general anesthesia., (Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.)

Electroencephalogram (EEG) signals, as it can express the human brain's activities and reflect awareness, have been widely used in many research and medical equipment to build a noninvasive monitoring index to the depth of anesthesia (DOA). Bispectral (BIS) index monitor is one of the famous and important indicators for anesthesiologists primarily using EEG signals when assessing the DOA. In this study, an attempt is made to build a new indicator using EEG signals to provide a more valuable reference to the DOA for clinical researchers. The EEG signals are collected from patients under anesthetic surgery which are filtered using multivariate empirical mode decomposition (MEMD) method and analyzed using sample entropy (SampEn) analysis. The calculated signals from SampEn are utilized to train an artificial neural network (ANN) model through using expert assessment of consciousness level (EACL) which is assessed by experienced anesthesiologists as the target to train, validate, and test the ANN. The results that are achieved using the proposed system are compared to BIS index. The proposed system results show that it is not only having similar characteristic to BIS index but also more close to experienced anesthesiologists which illustrates the consciousness level and reflects the DOA successfully.

This study evaluated the depth of anesthesia (DoA) index using artificial neural networks (ANN) which is performed as the modeling technique. Totally 63-patient data is addressed, for both modeling and testing of 17 and 46 patients, respectively. The empirical mode decomposition (EMD) is utilized to purify between the electroencephalography (EEG) signal and the noise. The filtered EEG signal is subsequently extracted to achieve a sample entropy index by every 5-second signal. Then, it is combined with other mean values of vital signs, that is, electromyography (EMG), heart rate (HR), pulse, systolic blood pressure (SBP), diastolic blood pressure (DBP), and signal quality index (SQI) to evaluate the DoA index as the input. The 5 doctor scores are averaged to obtain an output index. The mean absolute error (MAE) is utilized as the performance evaluation. 10-fold cross-validation is performed in order to generalize the model. The ANN model is compared with the bispectral index (BIS). The results show that the ANN is able to produce lower MAE than BIS. For the correlation coefficient, ANN also has higher value than BIS tested on the 46-patient testing data. Sensitivity analysis and cross-validation method are applied in advance. The results state that EMG has the most effecting parameter, significantly. [ABSTRACT FROM AUTHOR]