1. Happy heart syndrome: role of positive emotional stress in takotsubo syndrome
- Author
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Ghadri, Jelena R., Sarcon, Annahita, Diekmann, Johanna, Bataiosu, Dana Roxana, Cammann, Victoria L., Jurisic, Stjepan, Napp, Lars Christian, Jaguszewski, Milosz, Scherff, Frank, Brugger, Peter, Jäncke, Lutz, Seifert, Burkhardt, Bax, Jeroen J., Ruschitzka, Frank, Lüscher, Thomas F., Templin, Christian, Schwyzer, Moritz, Franke, Jennifer, Katus, Hugo A., Burgdorf, Christof, Schunkert, Heribert, Thiele, Holger, Bauersachs, Johann, Tschöpe, Carsten, Rajan, Lawrence, Michels, Guido, Pfister, Roman, Ukena, Christian, Böhm, Michael, Erbel, Raimund, Cuneo, Alessandro, Kuck, Karl Heinz, Jacobshagen, Claudius, Hasenfuß, Gerd, Karakas, Mahir, Koenig, Wolfgang, Rottbauer, Wolfgang, Said, Samir M., Braun Dullaeus, Ruediger C., Cuculi, Florim, Banning, Adrian, Fischer, Thomas A., Vasankari, Tuija, Juhani Airaksinen, K. E., Fijalkowski, Marcin, Rynkiewicz, Andrzej, Opolski, Grzegorz, Dworakowski, Rafal, Maccarthy, Philip, Kaiser, Christoph, Osswald, Stefan, Galiuto, Leonarda, Crea, Filippo, Dichtl, Wolfgang, Franz, Wolfgang M., Empen, Klaus, Felix, Stephan B., Delmas, Clément, Lairez, Olivier, Erne, Paul, Prasad, Abhiram, University of Zurich, and Templin, Christian
- Subjects
Brain–heart connection ,Medizin ,heart failure ,030204 cardiovascular system & hematology ,Anger ,tako tsubo ,Chest pain ,Electrocardiography ,0302 clinical medicine ,media_common ,Broken heart syndrome ,medicine.diagnostic_test ,Brain-heart connection ,10093 Institute of Psychology ,Heart Failure/Cardiomyopathy ,Heart ,Syndrome ,Acute heart failure ,Takotsubo syndrome ,Cardiology and Cardiovascular Medicine ,10209 Clinic for Cardiology ,Cardiology ,medicine.symptom ,Cardiomyopathies ,medicine.medical_specialty ,media_common.quotation_subject ,610 Medicine & health ,UFSP13-4 Dynamics of Healthy Aging ,2705 Cardiology and Cardiovascular Medicine ,03 medical and health sciences ,Clinical Research ,Takotsubo Cardiomyopathy ,Internal medicine ,Post-hoc analysis ,medicine ,Humans ,takotsubo syndrome ,Psychiatry ,business.industry ,Stressor ,10060 Epidemiology, Biostatistics and Prevention Institute (EBPI) ,ta3121 ,medicine.disease ,10040 Clinic for Neurology ,Settore MED/11 - MALATTIE DELL'APPARATO CARDIOVASCOLARE ,Happiness ,Grief ,business ,030217 neurology & neurosurgery ,Stress, Psychological - Abstract
Aims Takotsubo syndrome (TTS) is typically provoked by negative stressors such as grief, anger, or fear leading to the popular term 'broken heart syndrome'. However, the role of positive emotions triggering TTS remains unclear. The aim of the present study was to analyse the prevalence and characteristics of patients with TTS following pleasant events, which are distinct from the stressful or undesirable episodes commonly triggering TTS. Methods and results Takotsubo syndrome patients with preceding pleasant events were compared to those with negative emotional triggers from the International Takotsubo Registry. Of 1750 TTS patients, we identified a total of 485 with a definite emotional trigger. Of these, 4.1% (n = 20) presented with pleasant preceding events and 95.9% (n = 465) with unequivocal negative emotional events associated with TTS. Interestingly, clinical presentation of patients with 'happy heart syndrome' was similar to those with the 'broken heart syndrome' including symptoms such as chest pain [89.5% (17/19) vs. 90.2% (412/457), P = 1.0]. Similarly, electrocardiographic parameters, laboratory findings, and 1-year outcome did not differ. However, in a post hoc analysis, a disproportionate higher prevalence of midventricular involvement was noted in 'happy hearts' compared with 'broken hearts' (35.0 vs. 16.3%, P = 0.030). Conclusion Our data illustrate that TTS can be triggered by not only negative but also positive life events. While patient characteristics were similar between groups, the midventricular TTS type was more prevalent among the 'happy hearts' than among the 'broken hearts'. Presumably, despite their distinct nature, happy and sad life events may share similar final common emotional pathways, which can ultimately trigger TTS. OA hybrid - CA extern
- Published
- 2016