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Start Over Author "Fiorentino, Andrea" Topic elasticity imaging techniques
3 results on '"Fiorentino, Andrea"'

1. Liver stiffness assessment by transient elastography suggests high prevalence of liver involvement in common variable immunodeficiency.

Author

Crescenzi L, Pecoraro A, Fiorentino A, Poto R, Varricchi G, Rispo A, Morisco F, and Spadaro G

Subjects
Adult, Cross-Sectional Studies, Female, Humans, Italy, Liver diagnostic imaging, Liver Cirrhosis diagnostic imaging, Liver Cirrhosis etiology, Liver Function Tests, Male, Middle Aged, Prevalence, ROC Curve, Retrospective Studies, Spleen diagnostic imaging, Common Variable Immunodeficiency complications, Elasticity Imaging Techniques, Liver pathology, Liver Cirrhosis epidemiology
Abstract

Background: Up to 50% of patients with common variable immunodeficiency (CVID) present persistently increased serum levels of liver enzymes and/or mild hepatomegaly. Ultrasound-based transient elastography (TE) is largely used for early detection of the progression of chronic liver diseases, but has never been employed in CVID. We performed a cross-sectional study to evaluate TE values in a cohort of adult CVID-patients., Methods: Full blood count, liver function test, liver and spleen sonogram and ultrasound-based TE were performed in 77 adult CVID patients. Demographic and clinical data were retrospectively collected from medical files., Results: 33.8% (26/77) patients presented increased TE values ranging from moderate fibrosis to cirrhosis. TE values were positively correlated with ALP, γGT, spleen longitudinal diameter and peripheral blood counts (no significant correlation with BMI, AST, ALT, total proteins, albumin, bilirubin and hemoglobin). Moreover, liver stiffness was higher in patients with the clinical phenotypes polyclonal lymphoproliferation and enteropathy, and patients with both these complications had an increased risk (OR: 7.14) of presenting pathologic TE values compared with those without anyone of these., Conclusions: Transient elastography is a useful tool to be used alongside clinical and laboratory data to assess liver involvement in CVID., (Copyright © 2019. Published by Elsevier Ltd.)

Published
2019
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3. Ultrasound-based transient elastography improves the detection of liver disease in common variable immunodeficiency

Author

Giuseppe Spadaro, Antonio Pecoraro, Ludovica Crescenzi, Filomena Morisco, Andrea Fiorentino, Pecoraro, A., Crescenzi, L., Fiorentino, Andrea, Morisco, F., and Spadaro, G.

Subjects
medicine.medical_specialty, Liver disease, Elasticity Imaging Techniques, business.industry, Common variable immunodeficiency, Ultrasound, medicine, Immunology and Allergy, Radiology, business, medicine.disease, Transient elastography
Abstract

Although liver biopsy represents the gold standard to ascertain the ethiopathology of liver disease, it is associated with a significant rate of complications and mortality. This is heightened, in the context of CVID, by the additional infectious risk due to the underlying immune defect.3 Indeed, we suggest that the assessment of liver stiffness by TE should be used alongside clinical, laboratory, and imaging tools to both improve the accuracy of detection of liver disease and select subjects eligible for liver biopsy. Further studies are needed to establish the optimal timing of re-screening, the actual power of this technique to diagnose liver involvement in a preclinical phase, and the degree of concordance between TE results and liver histopathologic findings.

Published
2019

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