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The article presents the results of research conducted with students of the career of Educational Intervention in the National Pedagogical University in Morelos. Its objective was to form competences for the self-regulation of apprenticeship learning and strengthen the students' autonomy in the learning processes, as well as theoretically generating and sustaining a system of psycho-pedagogical actions that mediate the development of self-regulation in the context of their professional training. The study is based on the historical-cultural approach and other theoretical conceptions that explain the self-regulation of learning and the formation of autonomous learners. It was carried out through the qualitative research approach and its methodological design articulates the principles of the genetic method and participatory action research. The results guarantee the relevance of educational processes and psychopedagogical mediation actions in the development of autonomy and self-regulation. [ABSTRACT FROM AUTHOR]