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This article discusses the prevalence of contact allergy to sodium metabisulfite (SMB) in Spain. The study found that out of 6,471 patients who were patch-tested with SMB, 2.1% had a positive reaction. The most commonly affected locations were the hands, and the most frequently involved products were topical medications and cosmetics. However, only 25.34% of positive reactions were considered currently relevant. The study concludes that the low current relevance of sensitization to SMB in Spanish patients suggests that it should only be included as a candidate allergen in the Extended Standard series in Spain with caution. [Extracted from the article]

Dear Editor, The Spanish Registry of Contact Dermatitis (REIDAC) is an active project of the Spanish Research Group on Contact Dermatitis and Skin Allergy (GEIDAC) to describe the epidemiology of allergic contact dermatitis (ACD) in Spain.[1] Since January 2019, in parallel with the European Society of Contact Dermatitis (ESCD), a series of allergens have been consecutively patched by the GEIDAC group. In this observational, multicentre study, 3629 patients were patch-tested to alkyl glucosides (DG and LG), from January 2019 to December 2021, with positive results in 30 of these (0.8%) (Table 1). Among these allergens are alkyl glucosides (AG).[[1]] AG are a family of nonionic surfactants synthesized through the condensation of glucose with long-chain fatty alcohols.[[3]] This makes the AG completely biodegradable, having recently increased their fame due to their ecological nature. [Extracted from the article]

Background: Fragrances constitute the second most frequent cause of allergic contact dermatitis in Spain. Objectives: To determine the rate of sensitization to the individual fragrances of fragrance mix (FM) I and FM II for each of the demographic and clinical factors included in the MOAHLFA (male, occupational dermatitis, atopic dermatitis, hand dermatitis, leg dermatitis, facial dermatitis, age) index. Methods: We conducted a 5‐year retrospective study in 23 Spanish centres. We identified the patients who had undergone patch testing with a specific fragrance series after reacting positively to fragrance markers in a baseline series. We obtained the MOAHLFA index items in this population, then calculated for each demographic and clinical factor the frequencies of sensitization to the individual fragrances of FM I and FM II. Results: A specific fragrance series was patch tested in 1013 patients. The most frequent allergens in men, women, children, and retired people were Evernia prunastri (16%), geraniol (16.6%), isoeugenol (17.9%), and geraniol (22.4%), respectively. Citral (20.5%) and hydroxyisohexyl 3‐cyclohexene carboxaldehyde (HICC) (14.5%) were the most common allergens in occupational eczemas and were also associated with a large proportion of hand and facial dermatitis. Conclusions: Frequency of sensitization to the individual fragrances of FM I and FM II varies with age, sex, affected body region, and history of occupational or atopic dermatitis. [ABSTRACT FROM AUTHOR]

Background Corticosteroids are among the most commonly used topical drugs. Contact allergy to these exists, but can be easily missed. Corticosteroid screening markers have been included in the baseline series with the aim of detecting most of the sensitized patients. Objectives To assess the prevalence of contact allergy to topical corticosteroids in Spain and examine the usefulness of corticosteroid markers to detect contact allergy to corticosteroids. Methods In total, 3699 patients referred to 20 dermatology departments across Spain for patch testing with the baseline series, including budesonide and tixocortol pivalate, were also tested with six supplementary corticosteroids (methylprednisolone aceponate, mometasone furoate, prednicarbate, clobetasol propionate, betamethasone 17-valerate, and betamethasone 17,21-dipropionate). Additionally, 2547 (68.8%) patients were tested with hydrocortisone 17-butyrate. Results Fifty-four patients showed positive reactions to at least one of all tested corticosteroids (1.46%). Thirty-nine (1.05%) reacted to at least one of the additionally tested corticosteroids; among these, 24 of 39 (61.5%) did not react to any of the corticosteroid allergy screening markers tested. Conclusions More than half of the patients who were allergic to the additionally tested corticosteroids were not detected with the corticosteroid allergy markers. An update of the corticosteroid allergy screening markers is encouraged, with consideration of group 3 corticosteroids. [ABSTRACT FROM AUTHOR]

Keywords: allergic contact dermatitis; formaldehyde sensitization; TRUE Test EN allergic contact dermatitis formaldehyde sensitization TRUE Test 358 359 2 08/16/21 20210901 NES 210901 The optimal formaldehyde (FA) concentration for patch testing that allows to identify true FA sensitization has been studied and discussed over time. RESULTS A total of 52 patients reacted positively to FA 2% aq. (4.57%); only 13 patients (1.14%) reacted to FA in the TRUE Test and all of them showed a positive reaction to FA 2% aq. [Extracted from the article]

A case study of 72-year-old man with eczema on the backs of both forearms after the application of a sunscreen, is presented. It mentions patient's allergic contact dermatitis caused by benzoic acid and lauryl glucoside in a sunscreen. It also mentions use of benzoic acid and lauryl glucoside in sunscreens is not associated with allergy diagnosis, in previous cases.