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Your search keyword '"Christoffers, W.A."' showing total 3 results
Start Over Author "Christoffers, W.A." Topic eczema
3 results on '"Christoffers, W.A."'

1. Is ascaridol het contact-allergeen in tea tree oil?

Author

Schuttelaar, M.L.A., Christoffers, W.A., Blömeke, B., Coenraads, P.J., and Public Health Research

Subjects
petrolatum, contact sensitization, oxidation, article, food and beverages, Melaleuca alternifolia, Tea tree oil, ascaridole, Allergic contact dermatitis, eczema, human, contact allergen, patch test
Abstract

Tea tree oil is used as a natural remedy, but is also a popular ingredient in household and cosmetic products. Oxidation of tea tree oil may result in degradation products, such as ascaridole, which may cause allergic contact dermatitis. We investigated the prevalence of sensitization to ascaridole, the optimal patch test concentration and we studied co-sensitization of ascaridole and oxidized tea tree oil. A total of 290 patiënts with eczema were patch tested with ascaridole 1%, 2% and 5% in petrolatum. Ascaridole 2% seems to be the most favorable patch test concentration based on the ratio of positive (5.5%), irritant (1.7%) and doubtful (4.1%) reactions. Six patients showed a positive reaction to oxidized tea tree oil. All patients with a positive reaction to tea tree oil showed a positive reaction to ascaridole. This finding suggests that ascaridole is contact allergen in tea tree oil. A total of 24 patients showed a positive reaction to ascaridole without a positive reaction to tea tree oil. Six out of these 24 patients were exposed to tea tree oil en developed eczema after using products containing tea tree oil. Patch testing with ascaridole elicits clinically relevant positive reactions, which are missed by patch testing with tea tree oil alone.

Published
2013

2. Patch test results of hand eczema patients: relation to clinical types.

Author

Boonstra, M.B., Christoffers, W.A., Coenraads, P.J., and Schuttelaar, M.L.A.

Subjects
*HAND diseases, *SKIN inflammation, *DISEASES in older women, *ECZEMA, *DIAGNOSIS, *PATIENTS
Abstract

Background Allergic contact dermatitis is a well-known cause of hand eczema, although the influence of contact allergens on different clinical types of hand eczema remains still unclear. Objective To identify most common positive tested allergens among hand eczema patients and to define the relation between specific contact allergies and clinical types of hand eczema according to the guidelines of the Danish Contact Dermatitis Group ( DCDG). Methods We included 1571 hand eczema subjects who were patch tested from 1 January 2002 to 31 December 2013. They were retrospectively classified according to the guidelines of the DCDG into six clinical types: recurrent vesicular hand eczema, chronic fissured hand eczema, hyperkeratotic palmar eczema, pulpitis, interdigital eczema and nummular hand eczema according to a newly developed flow chart. The prevalence of sensitizations and association with clinical type, atopic dermatitis, age and gender were studied. Results A total of 1395 subjects were classified into one of the six clinical types. The most frequently found clinical types were recurrent vesicular hand eczema (39.7%) and chronic fissured hand eczema (35.5%). Subjects with recurrent vesicular hand eczema were significantly more likely to have a contact allergy ( OR 1.55), whereas subjects with hyperkeratotic palmar eczema and pulpitis were less likely to be sensitized ( OR 0.51; OR 0.44). Overall, metals (nickel sulphate, cobalt chloride), fragrances and preservatives (methylchloroisothiazoline/methylisothiazoline, methyldibromoglutaronitrile) were the most frequent sensitizers in patients with hand eczema. This did not deviate in the different clinical types, although subjects with recurrent vesicular hand eczema were significantly more frequently sensitized to nickel sulphate and other allergens compared to other clinical types of hand eczema. Conclusion In the diagnostic work up of hand eczema subjects with recurrent vesicular hand eczema should be patch tested, especially women of older age, although the need for patch testing in males with hyperkeratotic palmar eczema might be less imperative. [ABSTRACT FROM AUTHOR]

Published
2015
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