1. Impact on Macrolide Resistance of Genetic Diversity of Mycobacterium abscessus Species
- Author
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Bor-En Jong, Ting-Shu Wu, Nan-Yu Chen, Cheng-How Yang, Chin-Chung Shu, Lih-Shinn Wang, Tsu-Lan Wu, Jang-Jhih Lu, Cheng-Hsun Chiu, Hsin-Chih Lai, and Wen-Hung Chung
- Subjects
Microbiology (medical) ,Protein Synthesis Inhibitors ,General Immunology and Microbiology ,Ecology ,Mycobacterium abscessus ,Physiology ,Mycobacterium Infections, Nontuberculous ,Cell Biology ,Microbial Sensitivity Tests ,Anti-Bacterial Agents ,Mycobacterium ,Infectious Diseases ,Drug Resistance, Bacterial ,Genetics ,Humans ,Point Mutation ,Macrolides ,Phylogeny - Abstract
Macrolides are the mainstays of the antimycobacterial regimens against Mycobacterium abscessus species (formerly Mycobacterium abscessus complex). erm (41) confers inducible macrolide resistance for M. abscessus subsp. bolletii strains, and the majority of M. abscessus subsp. abscessus T28 sequevars. Furthermore, the acquired macrolide resistance of M. abscessus species is due to a point mutation in rrl .
- Published
- 2022