1. Detailed Echocardiographic Measurements of Individual Chamber in a Chinese Cohort of Hypoplastic Left Heart Syndrome and Comparison with Normal Fetuses via Z-score Modeling.
- Author
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Wu PF, Li RZ, Zhang R, Zhang W, Li X, Zeng S, Liu M, Zhou Q, Su Z, and Lin YH
- Subjects
- China, Cohort Studies, Female, Gestational Age, Humans, Pregnancy, Echocardiography methods, Fetal Heart diagnostic imaging, Hypoplastic Left Heart Syndrome diagnostic imaging, Models, Statistical, Ultrasonography, Prenatal
- Abstract
Hypoplastic left heart syndrome (HLHS) is a rare, but exceptionally serious, congenital heart defect. We aimed to explore the best-fitted Z-score models for individual chamber dimension and to draw a comparison between fetuses with HLHS and the normal Chinese cohort. We made measurements of 1674 healthy fetuses and 79 fetuses with HLHS, undertaking echocardiography. Normal fetal cardiovascular Z-score formulae were established by curve-fitting with 5 algorithmic functions and weighted regression of absolute residuals. Classic linear models were fitted for left ventricular diameter against gestational age, and log-transformed linear-power models-were statistically better for left ventricular length, diameter of left atrium and ascending aorta. Fetuses with HLHS manifested significantly lower Z-score means (≤3.5) for these 4 parameters and the vast majority (∼90%) lay beyond -2. Overall, cardiovascular Z-score equations were reliably constructed in a larger Chinese cohort, and their application should benefit evaluation and diagnosis of HLHS., Competing Interests: Conflict of interest disclosure The authors have no conflicts of interest to disclose., (Copyright © 2019 World Federation for Ultrasound in Medicine & Biology. Published by Elsevier Inc. All rights reserved.)
- Published
- 2020
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