1. Association of the adiponectin gene (ADIPOQ) +45 T > G polymorphism with the metabolic syndrome among Han Chinese in Sichuan province of China.
- Author
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Xiaotong Li, Daying Wei, Huijing He, Jianhua Zhang, Chunxiu Wang, Mingju Ma, Bin Wang, Tao Yu, Li Pan, Fang Xue, Haiqing He, Weiwei Xu, Tingfang Pan, Qian Zuo, Ulf, Lindblad, and Guangliang Shan
- Subjects
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ADIPONECTIN , *GENETIC polymorphisms , *METABOLIC syndrome , *BLOOD pressure , *DYSLIPIDEMIA - Abstract
The metabolic syndrome is a cluster of abnormalities characterized by obesity, impaired glucose metabolism, hypertension or elevated blood pressure, and dyslipidemia. The aim of this study was to investigate the association of the adiponectin gene (ADIPOQ) +45 T > G polymorphism with the metabolic syndrome among Han Chinese in Sichuan province of China. A case-control design was used including 116 patients with the metabolic syndrome and 108 unrelated controls, matched on age and gender. The ADIPOQ +45G allele (TG+GG) had a significant association with risk of the metabolic syndrome (odds ratio=l.88, 95% confidence interval: 1.03-3.44, p=0.039) adjusted for education, physical activity, family history of related diseases, smoking and drinking, compared with subjects with TT genotype. The association between the ADIPOQ +45 T>G polymorphism and the metabolic syndrome was independent of multiple confounders. [ABSTRACT FROM AUTHOR]
- Published
- 2012