1. Early onset cerebral amyloid angiopathy following childhood exposure to cadaveric dura.
- Author
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Banerjee G, Adams ME, Jaunmuktane Z, Alistair Lammie G, Turner B, Wani M, Sawhney IMS, Houlden H, Mead S, Brandner S, and Werring DJ
- Subjects
- Adult, Age of Onset, Cadaver, Cancer Survivors, Cerebral Amyloid Angiopathy metabolism, Cerebral Amyloid Angiopathy pathology, Cerebral Amyloid Angiopathy physiopathology, Craniotomy, Dura Mater metabolism, Embolization, Therapeutic, Female, Hemangioma, Cavernous, Central Nervous System therapy, Humans, Iatrogenic Disease, Magnetic Resonance Imaging, Male, Middle Aged, Papilloma, Choroid Plexus surgery, Parotid Neoplasms therapy, Skull Fractures surgery, Amyloid beta-Peptides metabolism, Cerebral Amyloid Angiopathy diagnostic imaging, Dura Mater transplantation
- Abstract
Amyloid-β transmission has been described in patients both with and without iatrogenic Creutzfeldt-Jakob disease; however, there is little information regarding the clinical impact of this acquired amyloid-β pathology during life. Here, for the first time, we describe in detail the clinical and neuroimaging findings in 3 patients with early onset symptomatic amyloid-β cerebral amyloid angiopathy following childhood exposure to cadaveric dura (by neurosurgical grafting in 2 patients and tumor embolization in a third). Our observations provide further in vivo evidence that cerebral amyloid angiopathy might be caused by transmission of amyloid-β seeds (prions) present in cadaveric dura and have diagnostic relevance for younger patients presenting with suspected cerebral amyloid angiopathy. Ann Neurol 2019; 1-7 ANN NEUROL 2019;85:284-290., (© 2018 The Authors. Annals of Neurology published by Wiley Periodicals, Inc. on behalf of American Neurological Association.)
- Published
- 2019
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