1. Whole-body positron emission tomography in patients with HIV-1 infection.
- Author
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Scharko, Alexander M., Perlman, Scott B., Pyzalski, Robert W., Graziano, Franklin M., Sosman, James, and Pauza, C. David
- Subjects
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POSITRON emission tomography , *DIAGNOSTIC imaging , *MEDICAL radiography , *MEDICAL imaging systems , *HIV infections , *HIV-positive persons , *LYMPHOID tissue , *IMMUNE system , *COMPUTER-aided diagnosis , *TISSUES , *DRUG therapy - Abstract
Positron emission tomography with fluorine-18-deoxyglucose (FDG-PET) detects active lymphoid tissues during HIV-1 infection in man. We used FDG-PET to study anatomical correlates of HIV-1 infection in man. Whole-body FDG-PET images from 15 patients with HIV-1 showed distinct lymphoid tissue activation in the head and neck during acute disease, a generalised pattern of peripheral lymph-node activation at mid-stages, and involvement of abdominal lymph nodes during late disease. Unexpectedly, HIV-1 progression was evident by distinct anatomical correlates, suggesting that lymphoid tissues are engaged in a predictable sequence. Understanding the anatomy of HIV-1 infection could encourage use of surgical or radiological interventions to supplement chemotherapy. [ABSTRACT FROM AUTHOR]
- Published
- 2003
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