1. Drug response prediction in high-risk multiple myeloma.
- Author
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Vangsted, A.J., Helm-Petersen, S., Cowland, J.B., Jensen, P.B., Gimsing, P., Barlogie, B., and Knudsen, S.
- Subjects
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MULTIPLE myeloma treatment , *GENE expression profiling , *INDIVIDUALIZED medicine , *PROGRESSION-free survival , *MELPHALAN - Abstract
A Drug Response Prediction (DRP) score was developed based on gene expression profiling (GEP) from cell lines and tumor samples. Twenty percent of high-risk patients by GEP70 treated in Total Therapy 2 and 3A have a progression-free survival (PFS) of more than 10 years. We used available GEP data from high-risk patients by GEP70 at diagnosis from Total Therapy 2 and 3A to predict the response by the DRP score of drugs used in the treatment of myeloma patients. The DRP score stratified patients further. High-risk myeloma with a predicted sensitivity to melphalan by the DRP score had a prolonged PFS, HR = 2.4 (1.2–4.9, P = 0.014) and those with predicted sensitivity to bortezomib had a HR 5.7 (1.2–27, P = 0.027). In case of predicted sensitivity to bortezomib, a better response to treatment was found ( P = 0.022). This method may provide us with a tool for identifying candidates for effective personalized medicine and spare potential non-responders from suffering toxicity. [ABSTRACT FROM AUTHOR]
- Published
- 2018
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