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Introduction: Pandemics are global health crises that have caused millions of deaths, enormous socio-economic disruptions, and considerable public and global health security consequences. This study assessed Nigerians' knowledge, attitudes, and perceptions regarding preparedness for the next pandemics. Methods: A cross-sectional questionnaire-based national survey was conducted among 1276 respondents in Nigeria to determine public knowledge, attitudes, and perceptions of preparedness for future pandemics. Descriptive and inferential statistics were used for analyses. Results: Of the 1276 respondents to this survey, > 50% had not heard of the Spanish flu and Zika disease. Approximately half (594) of the respondents did not consider antimicrobial resistance a possible cause of future pandemics. Over an average proportion of respondents reported unsatisfactory knowledge (655, 51.3%) and poor perceptions (695, 54.5%) about pandemic preparedness. The respondents' good knowledge and satisfactory attitudes toward pandemic preparedness decreased with age. The respondents' education, age, and state of residence were significantly associated with good knowledge, satisfactory attitudes, and positive perceptions of pandemic preparedness with respondents with tertiary education levels being at least two times more likely to have these positive outcomes. Conclusion: This study revealed serious gaps in Nigerians' knowledge, attitudes, and perceptions of their readiness for upcoming pandemics. To protect Nigerians' health, emphasis should be placed on these issues by all stakeholders, including the government. [ABSTRACT FROM AUTHOR]

This study was carried out in selected poultry farms to determine the prevalence, distribution and antimicrobial resistance patterns in Salmonella serovars in Ogun State, South-western Nigeria. A total of 200 faecal samples were aseptically collected from the four geographical zones of Ogun State, Nigeria. Seventy-eight Salmonella isolates spread across 39 serovars and representing a prevalence of 39% was recovered. Salmonella Urbana (n=7), Salmonella Kingston (n=6) and Salmonella Agama (n=5) serovars were more commonly isolated. Resistance was most common to ciprofloxacin (29.5%; n=23/78). Multi-drug resistance (MDR) was observed in 15.4% (n=12/78) of the isolates spread across 7 serovars: S. Kentucky, S. Telelkebir, S. Virchow, S. Blockley, S. Chomedey, S. Haifa, and S. Isangi. The study showed the diversity of Salmonella serovars and the increasing trend of antimicrobial resistance in poultry farms in Ogun State, Southwestern Nigeria. [ABSTRACT FROM AUTHOR]

Background: Plant extracts were evaluated on poultry bacteria known to be threatening public health. This is to develop better bio-therapeutic agents from plant origin. Methods: Bacteria were isolated from water, feed, crop, gizzard and faeces of layer chicken. Isolates of interest (Escherichia coli, Salmonella enteritidis, Pseudomonas aeruginosa and Klebsiella oxytoca) were subjected to antibiotic susceptibility test. Resistant strains were further evaluated against different plant extracts in comparison to Meropenem (control) using agar diffusion method. Results: E. coli had the highest occurrence (53 %), followed by P. aeruginosa (25 %) and then S. enteritidis (13 %) while the least was K. oxytoca (9 %). Virtually all the isolates exhibited multi-antibiotic resistance (MAR) with gross resistance to Amoxicillin, Erythromycin and Cefuroxine. P. aeruginosa (75 %), S. enteritidis (75 %) and E. coli (63 %), had the highest MAR. Out of the 11 (100 %) plant extracts evaluated, 7 (64 %) were outstanding and showed varied levels of antibacterial activity. Specifically, methanol extract of Mangifera indica Julie cultivar leaf (MJLM) had the highest antibacterial activity, followed by Euadenia trifoliata stem bark (TB03) and Euadenia eminens leaf (TB05). P. aeruginosa was highly susceptible (81.81 %) to the extracts, followed by S. enteritidis (63.64 %) and then E. coli (27.27 %). Conclusions: MJLM and other extracts have proven to be promising extracts in which to search for bioactive components that can be developed into therapeutic drugs. This may help in the management of antibiotic resistant bacterial isolates from poultry chicken threatening public health. [ABSTRACT FROM AUTHOR]