1. Porous magnesium loaded with gentamicin sulphate and in vitro release behavior.
- Author
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Li, Qiuyan, Jiang, Guofeng, Wang, Dong, Wang, Huang, Ding, Liang, and He, Guo
- Subjects
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POROUS materials , *MAGNESIUM , *GENTAMICIN , *CONTROLLED release drugs , *BONE surgery , *POSTOPERATIVE period , *BUFFER solutions - Abstract
Our aim was to develop a biocompatible bone repair material that has the advantage of preventing postoperative infections. Finally, the porous magnesium (p-Mg) loaded with gentamicin sulphate (GS-loaded Mg-G) was fabricated. The GS release behavior of the GS-loaded Mg-G in phosphate buffer saline (PBS) was investigated. The effective release time of GS reached to 14 days. In addition, the effects of porosity and pore diameter of p-Mg on the GS release behavior of the GS-loaded Mg-G were studied. In the initial burst release stage, the GS release rate of the GS-loaded Mg-G increased with the increasing porosity or the increasing pore diameter of p-Mg. The GS-loaded Mg-G with larger original pore diameter has higher burst release of GS. Moreover, the in vitro antibacterial test of the GS-loaded Mg-G indicated that this biomaterial has obvious antibacterial effect. This study can provide information for p-Mg loaded with drug(s) as functional bone repair materials with drug-delivery capabilities. [ABSTRACT FROM AUTHOR]
- Published
- 2016
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