1. Natural and Synthetic Lactones Possessing Antitumor Activities
- Author
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Younghoon Kim, Sandip Sengupta, and Taebo Sim
- Subjects
natural lactones ,synthetic lactones ,anticancer activities ,natural product synthesis ,drug discovery ,Biology (General) ,QH301-705.5 ,Chemistry ,QD1-999 - Abstract
Cancer is one of the leading causes of death globally, accounting for an estimated 8 million deaths each year. As a result, there have been urgent unmet medical needs to discover novel oncology drugs. Natural and synthetic lactones have a broad spectrum of biological uses including anti-tumor, anti-helminthic, anti-microbial, and anti-inflammatory activities. Particularly, several natural and synthetic lactones have emerged as anti-cancer agents over the past decades. In this review, we address natural and synthetic lactones focusing on their anti-tumor activities and synthetic routes. Moreover, we aim to highlight our journey towards chemical modification and biological evaluation of a resorcylic acid lactone, L-783277 (4). We anticipate that utilization of the natural and synthetic lactones as novel scaffolds would benefit the process of oncology drug discovery campaigns based on natural products.
- Published
- 2021
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