1. SF2487, a new polyether antibiotic produced by Actinomadura
- Author
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Hiroomi Watabe, Yoshinori Orikasa, Masahiro Hatsu, Shinichi Kondo, Yoshio Kodama, Shinji Miyadoh, Shigeharu Inouye, Haruo Yamamoto, Takashi Shomura, Kenzo Kajii, Yasuo Takeuchi, Toru Sasaki, and Masaji Sezaki
- Subjects
Nocardiaceae ,Magnetic Resonance Spectroscopy ,Spectrophotometry, Infrared ,medicine.drug_class ,Stereochemistry ,Antibiotics ,Virus ,Microbiology ,Mice ,X-Ray Diffraction ,Drug Discovery ,medicine ,Animals ,Actinomadura ,Furans ,Soil Microbiology ,Pharmacology ,biology ,Bacteria ,Molecular Structure ,Chemistry ,Biological activity ,biology.organism_classification ,Anti-Bacterial Agents ,Fermentation ,Actinomycetales - Abstract
A new antibiotic SF2487 has been isolated from the culture broth of Actinomadura sp. SF2487. The structure of antibiotic SF2487 was determined by spectroscopic analyses of the sodium salt and X-ray diffraction analysis of the silver salt. The antibiotic represents a new member of polyether group antibiotics known as the acyltetronic acid type 4. The antibiotic is weakly active against Gram-positive bacteria and exhibits antiviral activity against influenza virus in vitro.
- Published
- 1990