1. C-H activation reactions as useful tools for medicinal chemists.
- Author
-
Caro-Diaz EJE, Urbano M, Buzard DJ, and Jones RM
- Subjects
- Catalysis, Chemistry, Pharmaceutical methods, Heterocyclic Compounds chemistry, Hydrocarbons, Aromatic chemistry, Pharmaceutical Preparations chemistry, Chemistry Techniques, Synthetic methods, Drug Discovery methods, Heterocyclic Compounds chemical synthesis, Hydrocarbons, Aromatic chemical synthesis, Pharmaceutical Preparations chemical synthesis
- Abstract
In recent years, there has been an exponential rise in the number of reports describing synthetic methods that utilize catalytic sp
3 and sp2 C-H bond activation. Many have emerged as powerful synthetic tools for accessing biologically active motifs. Indeed, application to C-C and C-heteroatom bond formation, provides new directives for the construction of new pharmaceutical entities. Herein, we highlight some recent novel C-H activation processes that exemplify the utility of these transformations in medicinal chemistry., (Copyright © 2016 Elsevier Ltd. All rights reserved.)- Published
- 2016
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