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Start Over Author "Akihiko Okano" Topic drug discovery
2 results on '"Akihiko Okano"'

1. Contents, Vol. 37, Supplement 1, 1991

Author

Tatsu Ishii, Takafumi Suda, Miriam Gargiulo, Sonia Moretti, Joichi Kumazawa, Izumi Shichi, H. Bourdeau, J. Degelau, Simonetta Di Fabio, H. Giamarellou, Vito Trinchieri, Kosaku Eto, Y. Perol, L.E. Nicolle, B. Meyers, Eiichi Ohtomo, Yutaka Saito, I. Hirsch, Minoru Okuma, Kiyoshi Ishida, P. Sfikakis, Nobutsugu Teramoto, Takahide Nagase, C. Arlet, Sonia Tzantzoglou, J. Cullison, J.T. Smith, Kingo Chida, P. Alessi, E. Gluckman, Claudio De Simone, Tetsuro Matsumoto, Hajime Orimo, Masaro Tashima, E. Rubinstein, Atsuhiko Sato, Shogo Ueda, Yoshiro Sawae, Masatoshi Iwata, C. Roudet, Hiroyoshi Sawada, Masatoshi Yokouchi, Makoto Yamaoka, A. Dontas, Akihiko Okano, Yoshinosuke Fukuchi, Yoshiaki Yushita, G. Petrikkos, M. Iakovou, A. Devergie, and M. Pistoni

Subjects
Pharmacology, Infectious Diseases, Oncology, Drug Discovery, Pharmacology (medical), General Medicine
Published
1991
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2. Long-term effects of ofloxacin on clinical courses in patients with diffuse panbronchiolitis

Author

Takafumi Suda, Akihiko Okano, Kingo Chida, Masatoshi Iwata, Atsuhiko Sato, and Izumi Shichi

Subjects
Male, medicine.medical_specialty, Ofloxacin, Exacerbation, Pulmonary function testing, Internal medicine, Drug Discovery, medicine, Humans, Pharmacology (medical), In patient, Respiratory system, Pharmacology, business.industry, Incidence (epidemiology), General Medicine, Middle Aged, medicine.disease, Surgery, Oxygen tension, Respiratory Function Tests, Infectious Diseases, Oncology, Bronchiolitis, Drug Evaluation, Female, business, Diffuse panbronchiolitis, medicine.drug, Follow-Up Studies
Abstract

To ascertain the long-term effects of ofloxacin (OFX) on clinical parameters in cases of diffuse panbronchiolitis (DPB), we treated 18 patients with this disease with OFX and compared the clinical findings before and after treatment. Pulmonary function tests including percent vital capacity, arterial oxygen tension and arterial-alveolar oxygen tension difference significantly improved with OFX. In addition, the incidence of acute exacerbation and the duration of hospitalization were reduced. These observations indicate that OFX is a useful drug for the management of chronic respiratory infections such as DPB.

Published
1991

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