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Your search keyword '"Jeon, Jongho"' showing total 2 results
Start Over Author "Jeon, Jongho" Topic drug design
2 results on '"Jeon, Jongho"'

1. Positron Emission Tomography Imaging of Drug-Induced Tumor Apoptosis with a Caspase-Triggered Nanoaggregation Probe.

Author

Shen, Bin, Jeon, Jongho, Palner, Mikael, Ye, Deju, Shuhendler, Adam, Chin, Frederick T., and Rao, Jianghong

Subjects
*POSITRON emission tomography, *APOPTOSIS, *DOXORUBICIN, *TUMOR diagnosis, *RING formation (Chemistry)
Abstract

Drug Design: An 18F‐labeled caspase‐3‐sensitive nanoaggregation positron emission tomography tracer was prepared and evaluated for imaging the caspase‐3 activity in doxorubicin‐treated tumor xenografts. Enhanced retention of the 18F activity in apoptotic tumors is achieved through intramolecular macrocyclization and in situ aggregation upon caspase‐3 activation (see picture). [ABSTRACT FROM AUTHOR]

Published
2013
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2. Inside Cover: Positron Emission Tomography Imaging of Drug-Induced Tumor Apoptosis with a Caspase-Triggered Nanoaggregation Probe (Angew. Chem. Int. Ed. 40/2013).

Author

Shen, Bin, Jeon, Jongho, Palner, Mikael, Ye, Deju, Shuhendler, Adam, Chin, Frederick T., and Rao, Jianghong

Subjects
*POSITRON emission tomography, *DOXORUBICIN, *XENOGRAFTS
Abstract

The caspase‐3 activity in doxorubicin‐treated tumor xenografts is studied by positron emission tomography (PET) using a novel 18F‐labeled caspase‐3‐sensitive nanoaggregation tracer. In their Communication on page 10511 ff., J. Rao, F. T. Chin, et al. show that the enzyme‐activatable tracer improves the PET imaging of apoptotic tumors by intramolecular macrocyclization and in situ aggregation of the cyclized tracer upon caspase‐3 activation. (Picture: Jim Strommer and Lydia‐Marie Joubert.) [ABSTRACT FROM AUTHOR]

Published
2013
Full Text
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