1. Pinocembrin polymeric micellar drug delivery system: preparation, characterisation and anti-hyperuricemic activity evaluation.
- Author
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Rong W, Shen X, Adu-Frimpong M, He Q, Zhang J, Li X, Xia X, Shi F, Cao X, Ji H, Toreniyazov E, Wang Q, Yu J, and Xu X
- Subjects
- Administration, Oral, Animals, Biological Availability, Drug Carriers chemistry, Flavanones, Particle Size, Polymers chemistry, Rats, Rats, Sprague-Dawley, Solubility, Drug Delivery Systems methods, Micelles
- Abstract
Aim: Hydrophobic pinocembrin (PCB) was incorporated into a new nano-drug delivery system to enhance solubility, bioavailability and anti-hyperuricemic activity of the drug. Methods: We fabricated PCB loaded polymeric micelles (PCB-FPM) by thin film dispersion method and appropriately determined their physical characteristics. The oral relative bioavailability and anti-hyperuricemic activity of PCB-FPM and free PCB were observed. Results: The optimum particle size of the micelles was 19.90 ± 0.93 nm. PCB-FPM exhibited great stability within 18 days, coupled with lower cytotoxicity and higher biocompatibility. Moreover, the percent cumulative release of PCB-FPM was much higher than free PCB in the dissolution media. The oral bioavailability of PCB-FPM was increased by 2.61 times compared with free PCB. Uric acid (UA) level of rats was reduced in PCB-FPM group (200 mg/kg) by 78.82% comparable to the model control. Conclusion: PCB-FPM may become an ideal strategy to increase oral in-vivo availability and anti-hyperuricemic activity of PCB.
- Published
- 2022
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