1. New drug approvals for 2021: Synthesis and clinical applications.
- Author
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Yuan S, Wang DS, Liu H, Zhang SN, Yang WG, Lv M, Zhou YX, Zhang SY, Song J, and Liu HM
- Subjects
- Drug Discovery, United States, United States Food and Drug Administration, Humans, Biological Products pharmacology, Biological Products therapeutic use, Biological Products chemistry, Drug Approval, Pharmaceutical Preparations chemical synthesis, Pharmaceutical Preparations chemistry
- Abstract
50 New drugs including 36 chemical entities and 14 biologics were approved by the U.S. Food and Drug Administration during 2021. Among the marketed drugs, 31 new small molecule agents (29 small molecule drugs and 2 diagnostic agents) with privileged structures and novel clinical applications represent as promising leads for the development of new drugs with the similar indications and improved therapeutic efficacy. This review is mainly focused on the clinical applications and synthetic methods of 29 small molecule drugs newly approved by the FDA in 2021. We believed that insight into the synthetic approaches of drug molecules would provide creative and practical inspirations for the development of more efficient and practical synthetic technologies to meet with new drug discovery., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2022 Elsevier Masson SAS. All rights reserved.)
- Published
- 2023
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