1. Timing of exposure in angiographic computed tomography.
- Author
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Schad, Nikolaus, Schepke, Peter, Rohde, Ulrike, Schepke, Heidi, Schmid, Volker, Breit, Alfred, Schad, N, Schepke, P, Rohde, U, Schepke, H, Schmid, V, and Breit, A
- Subjects
HEART metabolism ,ANGIOGRAPHY ,COMPARATIVE studies ,COMPUTED tomography ,DIAGNOSTIC imaging ,HEART ,HEART beat ,RESEARCH methodology ,MEDICAL cooperation ,RESEARCH ,TECHNETIUM ,TIME ,EVALUATION research ,CONTRAST media ,DRUG administration ,DRUG dosage - Abstract
Visualization of heart chambers or the abdominal arterial phase on one of two CT-scans was achieved in 89.4% of 169 injections (91 patients) using only 30 ml of contrast medium (370 mg iodine/ml), when the start of scanning was accurately timed at predicted bolus peak concentration. Normal arrival times and numer of transit cycles to the bolus concentration maximum in the right (RV) and left ventricle (LV) after injection of a small radionuclide bolus of technetium-99 m were related to the patient's heart rate (HR) in a group of 200 patients. For the RV, mean arrival times varied significantly between 2.31 (HR: 90-109 beats per minute) and 3.46 seconds (HR: 50-59 beats per minute), mean number of transit cycles between 4.1 and 3.5. For the LV, mean arrival times varied significantly between 6.92 (HR: 90-109 beats per minute) and 11.37 seconds (HR: 50-59 beats per minute), and the mean number of transit cycles between 11.5 and 10.7. Washout from the LV lasted between an average of 9.2 (HR: 90-109 beats per minute) and 8.5 cycles (HR: 50-59 beats per minute). Contrary to actual transit times, there was no significant difference in the number of transit heart cycles for heart rates between 60 and 109 beats per minute, so that to determine the scan starting time, the patient's cycle length (60 divided by heart rate) had only to be multiplied by the corresponding normal value of transit cycles, i.e., four for the RV, 11 for the LV, and 13 for the abdominal arteries. By applying the estimated values, the result was negative on two successive scans in only 10.6% because of failure in coordination on the part of the operators or bolus transit delays (due to severe heart failure, severe lung disease, recent thoracotomy, or small veins disease). With automatic triggering of the scanner by a timer and injector and with a flush of saline after injection, results can be further improved. [ABSTRACT FROM AUTHOR]
- Published
- 1981
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