1. Cardiotonic Activity of Daidzein Against Doxorubicin-Induced Congestive Cardiac Failure in Rats
- Author
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Shuai Liu, Zhanhu Li, Yong Li, Yuan Li, and Yakun Su
- Subjects
chemistry.chemical_compound ,Nutrition and Dietetics ,chemistry ,business.industry ,Daidzein ,medicine ,food and beverages ,Medicine (miscellaneous) ,Doxorubicin ,Pharmacology ,business ,medicine.drug - Abstract
Despite significant medical advances, congestive heart failure remains associated with high mortality rate. Therefore, there is a continuing need for better therapeutics. In this study, we have examined the effect of daidzein against congestive heart failure induced by administration of doxorubicin. Blood pressure, electrocardiogram, B-type natriuretic peptide, and markers of oxidative stress were assessed as measures of cardioprotective effect of daidzein. To further assess the mechanism, terminal deoxynucleotidyl transferase-mediated dUTP nick-end labeling assay, Western blot assay, and histopathology were performed. Daidzein reduced blood pressure, reversed the altered pattern of electrocardiogram, levels of B-type natriuretic peptide, and oxidative stress markers in doxorubicin-induced cardiotoxicity in rats. Furthermore, treatment with daidzein ameliorated apoptosis and expression of proinflammatory proteins and oxidative pathway.
- Published
- 2021
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