1. Doxorubicin-loaded micelles of amphiphilic diblock copolymer with pendant dendron improve antitumor efficacy: In vitro and in vivo studies.
- Author
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Voon SH, Kue CS, Imae T, Saw WS, Lee HB, Kiew LV, Chung LY, and Yusa SI
- Subjects
- Animals, Anthracenes chemistry, Breast Neoplasms drug therapy, Cell Line, Tumor, Drug Carriers chemistry, Female, Mice, Mice, Inbred BALB C, Micelles, Nanoparticles chemistry, Tissue Distribution drug effects, Antineoplastic Agents pharmacology, Doxorubicin chemistry, Doxorubicin pharmacology, Polymers chemistry
- Abstract
Previously reported amphiphilic diblock copolymer with pendant dendron moieties (P
71 D3 ) has been further evaluated in tumor-bearing mice as a potential drug carrier. This P71 D3 -based micelle of an average diameter of 100nm was found to be biocompatible, non-toxic and physically stable in colloidal system up to 15days. It enhanced the in vitro potency of doxorubicin (DOX) in 4T1 breast tumor cells by increasing its uptake, by 3-fold, compared to free DOX. In 4T1 tumor-bearing mice, the tumor growth rate of P71 D3 /DOX (2mg/kg DOX equivalent) treated group was significantly delayed and their tumor volume was significantly reduced by 1.5-fold compared to those treated with free DOX. The biodistribution studies indicated that P71 D3 /DOX enhanced accumulation of DOX in tumor by 5- and 2-fold higher than free DOX treated mice at 15min and 1h post-administration, respectively. These results suggest that P71 D3 micelle is a promising nanocarrier for chemotherapeutic agents., (Copyright © 2017 Elsevier B.V. All rights reserved.)- Published
- 2017
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