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4. LEU-ARG ANALOGUES: SYNTHESIS, IR CHARACTERIZATION AND DOCKING STUDIES.

Author

Dzimbova, Tatyana, Chapkanov, Atanas, and Pajpanova, Tamara

Subjects
OPIOID receptors, PROTEIN-tyrosine kinases, ARGININE, NEUROPEPTIDES, ANALGESIA
Abstract

Leu-Arg is a kyotorphin receptor antagonist. It is very important to control antinociception and this could be achieved by modifications in agonist's or antagonist's molecules. Two analogues of Leu-Arg were synthesized, their IR- spectral characteristics were defined, and preliminary docking studies were performed. The results show that new analogues bind receptor thus they could be used for further analysis and their biological activity could be tested in vitro and in vivo. [ABSTRACT FROM AUTHOR]

Published
2015

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