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We found that the most prevalent subgroups were the CNH subgroup (42.5%) and the CNL subgroup (40.9%), while the MSI subgroup (9.8%) and the POLE subgroup (3.8%) were less common (Figure). In fact, the CNL subgroup (also referred to as the "endometrioid" subgroup) typically includes hormone-responsive, low-grade endometrioid carcinomas, which have a good-to-intermediate prognosis.[1] Conversely, the CNH subgroup (also referred to as the "serous" subgroup) is mainly composed of serous carcinomas and bears the worst prognosis among all TCGA subgroups.[1] Therefore, it might be hypothesized that some CCCs are biologically similar to endometrioid carcinoma and have a better prognosis, while some are similar to serous carcinomas and have a poorer prognosis. Targeted molecular and immunohistochemical analyses of endometrial clear cell carcinoma show that POLE mutations and DNA mismatch repair protein deficiencies are uncommon. [Extracted from the article]