1. DDR1 methylation is associated with bipolar disorder and the isoform expression and methylation of myelin genes
- Author
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Edith Pomarol-Clotet, Elisabet Vilella, Gerard Muntané, Elena Bosch, Beatriz Garcia-Ruiz, Erick J. Canales-Rodríguez, Manel Esteller, Lourdes Martorell, Manuel Castro de Moura, Eduard Vieta, Esther Jiménez, García- Ruiz, Beatriz, Castro de Moura, Manuel, Muntané, Gerard, Martorell, Lourdes, Bosch, Elena, Esteller, Manel, Canales-Rodríguez, Erick Jorge, Pomarol-Clotet, Edith, Jiménez, Esther, Vieta, Eduard, Vilella, Elisabet, García- Ruiz, Beatriz [0000-0001-9552-949X], Castro de Moura, Manuel [0000-0002-8488-5306], Muntané, Gerard [0000-0003-1541-8365], Martorell, Lourdes [0000-0003-4999-2197], Bosch, Elena [0000-0003-2848-103X], Esteller, Manel [0000-0003-4490-6093], Canales-Rodríguez, Erick Jorge [0000-0001-6421-2633], Pomarol-Clotet, Edith [0000-0002-8159-8563], Jiménez, Esther [0000-0001-6929-6207], Vieta, Eduard [0000-0002-0548-0053], and Vilella, Elisabet [0000-0002-1887-5919]
- Subjects
Gene isoform ,Cancer Research ,Bipolar disorder ,Human brain ,Biology ,Methylation ,Myelin genes ,Myelin ,Gene expression ,Genetics ,medicine ,human brain ,Gene ,bipolar disorder ,DDR1 ,Discoidin domain receptor 1 ,Molecular biology ,discoidin domain receptor 1 ,medicine.anatomical_structure ,DNA methylation ,gene expression ,methylation ,myelin genes - Abstract
[Aim] To investigate DDR1 methylation in the brains of bipolar disorder (BD) patients and its association with DDR1 mRNA levels and comethylation with myelin genes., [Materials & methods] Genome-wide profiling of DNA methylation (Infinium MethylationEPIC BeadChip) corrected for glial composition and DDR1 gene expression analysis in the occipital cortices of individuals with BD (n = 15) and healthy controls (n = 15) were conducted., [Results] DDR1 5-methylcytosine levels were increased and directly associated with DDR1b mRNA expression in the brains of BD patients. We also observed that DDR1 was comethylated with a group of myelin genes., [Conclusion] DDR1 is hypermethylated in BD brain tissue and is associated with isoform expression. Additionally, DDR1 comethylation with myelin genes supports the role of this receptor in myelination.
- Published
- 2021