1. Methodological considerations for mutagen exposure in C. elegans.
- Author
-
Kessler Z and Yanowitz J
- Subjects
- Animals, Caenorhabditis elegans drug effects, DNA Repair drug effects, Caenorhabditis elegans genetics, DNA Damage drug effects, Genome drug effects, Mutagens toxicity
- Abstract
Maintenance of the genome requires the continual repair of DNA lesions. Exposure of nematodes to DNA damage-inducing agents is a powerful method to rapidly ascribe a role for specific genes in DNA repair and to define epistatic relationships to other repair genes which allows for the construction of repair pathways. Despite the extensive use of these agents, however, differences in dosing, timing, and handling makes it difficult to compare results across laboratories. We provide herein a consideration of the parameters that influence the results of these exposures and detailed protocols for the exposure to mutagenic inducing agents., (Copyright © 2014 Elsevier Inc. All rights reserved.)
- Published
- 2014
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