1. Model of DNA Dynamics and Replication.
- Author
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Matsson, Leif
- Subjects
- *
DYNAMICS , *DNA replication , *CELL cycle , *T cells , *GROWTH factors , *BIOPHYSICS - Abstract
Before DNA replication can be initiated a definite number of adenosine triphosphate (ATP) containing pre-replication protein complexes (pre-RCs) must be assembled and bound to DNA like in a super-critical mass. A chemically driven dynamics of the Ginzburg-Landau (GL) type is derived, using the non-equilibrium equation for binding of pre-RCs to DNA and a probabilistic conformational distribution of these protein complexes. This dynamics, in which the DNA-protein system behaves like a nonlinear elastically braced string (NEBS), can control the cell cycle via conformational transitions such that G 2 cells contain exactly twice as much DNA as G 1 cells. After adjustment of previously-made derivations, the model is compared with cell growth data from the T lymphocyte MLA-144. [ABSTRACT FROM AUTHOR]
- Published
- 2005
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