1. Interactions of selected gold(iii) complexes with DNA G quadruplexes.
- Author
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Gratteri, P., Massai, L., Michelucci, E., Rigo, R., Messori, L., Cinellu, M. A., Musetti, C., Sissi, C., and Bazzicalupi, C.
- Subjects
GOLD compounds ,COMPLEX compounds ,NUCLEOTIDE sequencing ,DNA analysis ,DICHROISM - Abstract
The interactions of three representative gold(iii) complexes with human telomeric DNA sequences were analysed using a variety of biophysical methods, including DNA melting, circular dichroism, SPR and ESI MS; remarkable interactions were highlighted for all tested complexes, although they were associated to significantly different binding profiles. The most interesting compound was Auoxo6, a dinuclear gold(iii) complex, which beyond manifesting a conspicuous binding affinity for the G-quadruplex conformation, turned out to be very effective in inducing a non-canonical secondary structure. These findings may clear the way for novel biological and pharmacological applications of this class of metal compounds. [ABSTRACT FROM AUTHOR]
- Published
- 2015
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